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KMID : 0613820110210070932
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Journal of Life Science
2011 Volume.21 No. 7 p.932 ~ p.938
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Antihyperlipidemic Effect of Ginsenoside Rg1 in Type 2 Diabetic Mice
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Park Jae-Hong
Lee Ji-Youn
Yeo Ji-Young
Nam Jeong-Su
Jung Myeong-Ho
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Abstract
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Ginsenoside Rg1 is a pharmacologically active component isolated from ginseng. The goal of this study was to clarify the beneficial effects of Rg1 on glucose and lipid metabolism in diabetic animals (db/db mice). To accomplish this, ten week old db/db mice were administered 10 ㎎/㎏ of Rg1 for 15 days. Rg1 did not influence the weight of db/db mice when compared with vehicle-treated db/db mice. The administration of Rg1 lowered fasting plasma glucose, and improved glucose tolerance. Importantly, Rg1 markedly reduced both plasma triglyceride and free fatty acids, and increased high-density lipoprotein cholesterol (HDL-C) concentrations in db/db mice. Rg1 activated promoter activity of chimeric GAL4-PPARα reporter and increased expression of peroxisome proliferator-activated receptor alpha (PPARα) target genes such as carnitine palmitoyltransferase-1 (CPT-1) and acyl-CoA oxidase (ACO), which are involved in fatty acid oxidation. These findings indicated that improvement of lipid profiles by Rg1 may be associated with increased fatty acid oxidation via PPARα activation. Taken together, these results suggest that Rg1 could have beneficial effects for controlling hyperglycemia and hyperlipidemia associated with type 2 diabetes.
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KEYWORD
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Ginsenoside Rg1, type 2 diabetes, hyperlipidemia, db/db mice
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